metabolic dysfunction and unabated

Metabolic insights from zebrafish genetics physiology

Global metabolic disease burden The World Health Organization recently reaffirms that cardiovascular disease remains the leading killer of adults [] it is expected that global mortality from non-communicable diseases will increase in the coming decades with cardiovascular disease leading the way [] This prediction is informed by the unabated increase in the prevalence of cardiovascular risk

Metabolic Inflexibility: When Mitochondrial Indecision

Mitochondria can generate cellular energy from different fuel sources including glucose fatty acids and amino acids but mitochondrial cellular and ultimately organismal health founders when switching between fuels becomes inefficient under conditions of nutrient excess This Perspective lays out an integrated network of metabolic and cell signaling events that enables crosstalk and

Metabolic Inflexibility: When Mitochondrial Indecision

Dec 04 2014Metabolic inflexibility can also be induced experimentally in rodents with high-fat feeding (Koves et al 2008 Newgard 2012) or as a consequence of one of numerous and disparate genetic manipulations used to mimic various metabolic disease states (Asterholm et al 2012b Koves et al 2008 Vadvalkar et al 2013) In many cases mitochondrial capacity to switch between fuels is

Various Terpenoids Derived from Herbal and Dietary Plants

This unabated rise has spawned proportionate increases in obesity-associated metabolic disorders Currently synthetic PPAR agonists are widely used for the treatment of metabolic disorders Daily intake of dietary terpenoids which activate PPARs as we described above may be valuable for the control of carbohydrate and lipid disorders

Cardiovascular and Metabolic Diseases

The increased prevalence of cardiovascular and metabolic disorders (e g hypertension atherosclerosis heart failure diabetes etc ) poses an enormous risk for the inhabitants of Singapore and the world With an aging and increasingly sedentary population the unabated rise in these diseases is unlikely to slow in the near future and

CiteSeerX — EDUCATIONAL REVIEW Nephrolithiasis related to

CiteSeerX - Document Details (Isaac Councill Lee Giles Pradeep Teregowda): Abstract Nephrolithiasis associated with inborn metabolic diseases is a very rare condition with some common characteristics: early onset of symptoms family history associated tubular impairment bilateral multiple and recurrent stones and association with nephrocalcinosis

Neuronal Regulation of Energy Homeostasis: Beyond the

Coupled with modern conveniences and an associated sedentary lifestyle these realities have led to an unabated increase in obesity metabolic disease and type II diabetes The costs attributed to this increase are devastating with an estimated hundreds of billions spent each year on

Therapeutic approaches to diabetic cardiomyopathy

The global epidemic of cardiovascular disease continues unabated and remains the leading cause of death both in the US and worldwide We hereby summarize the available therapies for diabetes and cardiovascular disease in diabetics insulin resistance and metabolic dysfunction Diabetes is a risk factor for atherosclerosis in large arteries

Therapeutic approaches to diabetic cardiomyopathy

The global epidemic of cardiovascular disease continues unabated and remains the leading cause of death both in the US and worldwide We hereby summarize the available therapies for diabetes and cardiovascular disease in diabetics insulin resistance and metabolic dysfunction Diabetes is a risk factor for atherosclerosis in large arteries

Metabolic Inflexibility: When Mitochondrial Indecision

Dec 04 2014Metabolic inflexibility can also be induced experimentally in rodents with high-fat feeding (Koves et al 2008 Newgard 2012) or as a consequence of one of numerous and disparate genetic manipulations used to mimic various metabolic disease states (Asterholm et al 2012b Koves et al 2008 Vadvalkar et al 2013) In many cases mitochondrial capacity to switch between fuels is

Adiponectin is markedly increased in patients with

May 01 2003Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors also independent of renal function unabated urinary protein loss triggers hypoalbuminemia hyperfibrinogenemia and hypercholesterolemia hypoalbuminemia and a hypercoagulable state Endothelial dysfunction is an early phase

CELL BIOLOGY Copyright 2019 Cancer

trum of human disease including cancer and neurodegeneration (1 2) Cancer has become a prime example of how genetically defined metabolic perturbation cause disease phenotypes To fulfill bioenergetic and biosynthetic demand associated with unabated growth and survival as first discovered by Otto Warburg more than

Translational Significance of Heme Oxygenase in Obesity

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2 biliverdin reductase and HO activity on vascular disease The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and

Pomegranate for Metabolic Syndrome

Metabolic Syndrome and its Disease Sequelae Cardiovascular disease represents the leading cause of morbidity and mortality worldwide (1) Metabolic syndrome on the other hand is an aggregate of risk factors including atherogenic dyslipidemia hypertension visceral adiposity and elevated plasma glucose that predict development of

The Sweet Path to Metabolic Demise: Fructose and Lipid

Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis Mark A Herman1 and Varman T 2 3 * Epidemiological studies link fructose consumption with metabolic disease an association attributable in part to fructose-mediated lipogenesis The mecha-nisms governing fructose-induced lipogenesis and disease remain debated Acutely excess

Dietary carbohydrate restriction in type 2 diabetes

Apr 08 2008Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat The success of such approaches has been limited and therapy more generally relies on pharmacology The argument is made that a re-evaluation of the role of carbohydrate restriction the historical and intuitive approach to the problem may provide an alternative and possibly

Cellular Therapy and Induced Neuronal Replacement for

the amelioration of mutant huntingtin-related metabolic impairment and cellular toxicity Each of these approaches has aimed to delay or stop the preferential degeneration of medium spiny neurons early in the disease course Yet in later stages of the disease after cell death has become prominent cell replacement therapy (whether by direct

Metabolic Dysfunction and Unabated Respiration Precede the

Feb 01 2000Metabolic Dysfunction and Unabated Respiration Precede the Loss of Membrane Integrity during Dehydration of Germinating Radicles Olivier Leprince Frans J M Harren Julia Buitink Mark Alberda Folkert A Hoekstra Plant Physiology Feb 2000 122 (2) 597-608 DOI: 10 1104/pp 122 2 597 Share This Article: Copy

Frontiers

Sep 14 2017Obesity is associated with increased risk and poor prognosis of many types of cancers Several obesity-related host factors involved in systemic metabolism can influence tumor initiation progression and/or response to therapy and these have been implicated as key contributors to the complex effects of obesity on cancer incidence and outcomes Such host factors include systemic metabolic

Highlighting Diabetes Mellitus

The defining feature of diabetes mellitus is the presence of hyperglycemia 1 The most common forms of diabetes mellitus are type 1 diabetes mellitus in which an absolute deficiency of insulin ensues consequent to pancreatic beta cell destruction and type 2 diabetes mellitus in which insulin resistance may lead to hyperglycemia 1 Obesity is an important risk factor for type 2 diabetes

Pomegranate for Metabolic Syndrome

Metabolic Syndrome and its Disease Sequelae Cardiovascular disease represents the leading cause of morbidity and mortality worldwide (1) Metabolic syndrome on the other hand is an aggregate of risk factors including atherogenic dyslipidemia hypertension visceral adiposity and elevated plasma glucose that predict development of

Nephrolithiasis related to inborn metabolic diseases

Jan 21 2009Nephrolithiasis associated with inborn metabolic diseases is a very rare condition with some common characteristics: early onset of symptoms family history associated tubular impairment bilateral multiple and recurrent stones and association with nephrocalcinosis The prognosis of such diseases may lead to life threatening conditions not only because of unabated kidney damage but

About the Cellular Signalling and Metabolic Disease Laboratory

About the Cellular Signalling and Metabolic Disease Laboratory Excess body weight is a major and leading factor in overall disease burden and if left unabated could lead to falls in life expectancy particularly in developed nations Notably the obesity epidemic is the single most important contributor to the development of type 2

syndrome PPARd: a dagger in the heart of the metabolic

unabated rise has spawned proportionate increases in obesity-asso-ciated metabolic disorders including glucose intolerance insulin resistance dyslipidemia and hypertension that are well-estab-lished risk factors for cardiovascular disease Known as the meta-

Metabolic dysfunction and unabated respiration precede the

Metabolic dysfunction and unabated respiration precede the loss of membrane integrity during dehydration of germinating radicles: Author(s) Leprince O Harren F J M Alberda M Hoekstra F A Source: Plant Physiology 122 (2000) - ISSN 0032-0889 - p 597 - 608 Department(s) Laboratory of Plant Physiology EPS: Publication type