a novel open-porous magnesium scaffold with

The mechanical and biological properties of a novel

The mechanical and biological properties of a novel biodegradable polycaprolactone -magnesium porous scaffold for bone tissue engineering 1Wong KHM 1 YeungKWK 2ChuPK 1Luk KDK +1Cheung KMC +1Department of Orthopaedics and Traumatology The University of Hong Kong Pokfulam Hong Kong China 2Department of Physics and Materials Science City University of Hong

Onkos Surgical announces the launch of GenVie™ a novel

PARSIPPANY N J Feb 6 2020 /PRNewswire/ — Onkos Surgical is pleased to announce the launch of GenVie™ Magnesium Bone Scaffold a novel biologic technology that further expands Onkos' reach in complex limb salvage procedures GenVie is the first 510(k) cleared magnesium-based bone void filler in the orthopaedic marketplace and is available via a private label distribution agreement

Bioresorbable stent

Magnesium-based scaffolds have been approved for use in several countries around the world The only commercially available magnesium-based scaffold consists of a magnesium alloy approximately 95% of which resorbs within one year of implantation Thousands of commercially available magnesium-based scaffolds have been implanted Promising

Porous Biodegradable Metals for Hard Tissue Scaffolds: A

Magnesium- (Mg-) based and iron- (Fe-) based metals have been used which include Mg-RE (rare earth elements) [29–33] Mg-Ca- [34 35] pure Fe [36 37] Fe-Mn alloys [38 39] and Fe foam for bone replacement scaffold Mg and its alloys have been proposed for orthopaedic implants due to their supportive physical properties to human bones

Alginate hydrogel

In this study a nanobiocomposite scaffold was fabricated by combining sodium alginate polyvinyl alcohol silk fibroin and magnesium hydroxide nanorods The structural characteristics and properties of the scaffold were identified by field emission scanning electron microscope (FE-SEM) thermogravi

Osteogenic magnesium incorporated into PLGA/TCP porous

Magnesium (Mg) as a biodegradable metal with properly mechanical properties has been investigating for a long history In this study Mg powder poly (lactide-co-glycolide) (PLGA) β-tricalcium phosphate (β-TCP) were the elements to formulate a novel porous PLGA/TCP/Mg (PTM) scaffolds using low temperature rapid prototyping (LT-RP) technology

Preclinical Evaluation of a Novel Sirolimus

Preclinical Evaluation of a Novel Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold in Porcine Coronary Artery at 6 Months Jian-Feng Zheng MSC aHong Qiu MD Yuan Tian BS b Xiao-Ying Hu MD a Tong Luo MD Chao Wu MD Yi Tian MD cYue Tang MD Lai-Feng Song MD dLi Li MD Liang Xu MD a Bo Xu MBBS a Run-Lin Gao MDa ABSTRACT

A novel porous magnesium production through powder

A novel porous magnesium production through powder metallurgy technique using wire-pieces of titanium space holder for bone scaffold materials Magnesium (Mg) and its alloys has a potential for the application for bone implant material as it's biocompatibility and mechanical properties that fit to

A novel open

Apr 01 2016The traditional production methods of porous magnesium scaffolds are difficult to accurately control the pore morphologies and simultaneously obtain appropriate mechanical properties In this work two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are successfully fabricated with high-purity Mg ingots through the titanium wire space holder (TWSH)

Porous fluorhydroxyapatite

Jun 01 2019In this regard Cheng et al showed that MG-63 cells were well grown and proliferate in open-porous magnesium scaffold Furthermore Kim et al presented scaffolds containing hydroxyapatite and Gel that could improve cell attachment of MG-63 cells However there is no research on fabricating FHA-Mg-Gel scaffolds and according to advantages

Osteopontin /OPN Antibody (1B20) NB110

(5) A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Scientific reports January 1 2016 Meng-Qi Cheng Tuerang Wahafu Guo-Feng Jiang Wei Liu Yu-Qin Qiao Xiao-Chun Peng Tao Cheng Xian-Long Zhang Guo He Xuan-Yong Liu

In vitro degradation behavior of Mg scaffolds with three

Nov 01 20181 Introduction Bone tissue engineering scaffolds provide a promising strategy to the regeneration of segmental bone defects [] To achieve good therapeutic effect the scaffold should have an open porous structure for tissue ingrowth and the exchange of nutrients and oxygen [] To allow a complete replacement by the regenerated host tissue the scaffold should be degradable without

Onkos Surgical announces the launch of GenVie™ a novel

Feb 06 2020PARSIPPANY N J Feb 6 2020 /PRNewswire/ -- Onkos Surgical is pleased to announce the launch of GenVie™ Magnesium Bone Scaffold a novel biologic technology that further expands Onkos' reach in complex limb salvage procedures GenVie is the first 510(k) cleared magnesium-based bone void filler in the orthopaedic marketplace and is available via a private label

Fabrication and characterization of magnesium scaffold

Mar 28 2018Cheng M Q Wahafu1 T Jiang G f Liu W Qiao Y Q Peng X C Cheng T Zhang X L He G and Liu X Y 2016 A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Sci Rep 6 1–14

Osteopontin /OPN Antibody (1B20) NB110

(5) A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration Scientific reports January 1 2016 Meng-Qi Cheng Tuerang Wahafu Guo-Feng Jiang Wei Liu Yu-Qin Qiao Xiao-Chun Peng Tao Cheng Xian-Long Zhang Guo He Xuan-Yong Liu

Impacts of dynamic degradation on the morphological and

This study employs a computational approach to analyse the impact of morphological changes on the structural properties of biodegradable porous Mg subjected to a dynamic immersion test for its application as a bone scaffold Porous Mg was immersed in a dynamic immersion test for 24 48 and 72 h Twelve specimens were prepared and scanned using micro-CT and then reconstructed into a 3D model

Tubular open

In combination with an additional autologous cancellous bone graft filling the scaffold's ability to work as an open-porous membrane to improve the defect healing process was analysed (group 2 n = 6) A novel model of a critical size (40 mm) tibia osteotomy defect stabilized with an external hybrid-ring fixator was established in sheep

The improvement of corrosion resistance biocompatibility

A magnesium scaffold is a promising biodegradable bone repair material However its poor corrosion resistance limits its clinical application In this study we improved the corrosion resistance biocompatibility and osteointergration ability of magnesium by alloying it with neodymium (Nd) and zinc (Zn) then fabricated a novel open-porous Mg

Endogenous Particle Stabilization During Magnesium

Meng-qi Cheng Tuerang Wahafu Guo-feng Jiang Wei Liu Yu-qin Qiao Xiao-chun Peng Tao Cheng Xian-long Zhang Guo He Xuan-yong Liu A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration

The improvement of corrosion resistance biocompatibility

A magnesium scaffold is a promising biodegradable bone repair material However its poor corrosion resistance limits its clinical application In this study we improved the corrosion resistance biocompatibility and osteointergration ability of magnesium by alloying it with neodymium (Nd) and zinc (Zn) then fabricated a novel open-porous Mg

Synthesis and characterization of a novel open cellular Mg

Jun 01 2019However fabrication of an open cell Mg-based scaffold with high porosity pore interconnectivity and significant strength is a challenging task due to the highly reactive nature of magnesium (Song 2007 Wang and Xiong 2013 Arifvianto and Zhou 2014) in a body fluid Several methods have been reported for producing Mg-based porous structures

Novel porous polysaccharide scaffolds for tissue

Jan 01 2005A three dimensional interconnected matrix of high porosity may be used as a scaffold for seeding cells for tissue reconstruction repair or remodeling This paper comprises a novel method for preparation of porous alginate scaffolds for tissue engineering of liver cartilage bone etc

Fatigue and quasi‐static mechanical behavior of bio

One of the methods is using Fe as a scaffold material as Fe has also shown biodegradation properties 45 46 Contrary to magnesium the main issue with Fe porous structures is their too slow degradation rate 4 47 One of the promising methods to decrease the degradation rate of magnesium down to the tissue healing speed is using coating or

Frontiers

Introduction: Biodegradable metals made of magnesium and its alloys have been investigated as implant materials for more than 100 years [1] But just recently first in vivo results confirmed the suitability of open-porous biodegradable scaffolds made from sintered magnesium fibers providing a stochstic distribution of pores [2] In this

Comparison of two pore sizes of LAE442 scaffolds and their

The magnesium alloy LAE442 emerged as a possible bioresorbable bone substitute over a decade ago In the present study using the investment casting process scaffolds of the Magnesium (Mg) alloy LAE442 with two different and defined pore sizes which had on average a diameter of 400 μm (p400) and 500 μm (p500) were investigated to evaluate degradation and osseointegration in comparison to

A novel open

Apr 13 2016A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are successfully fabricated with high-purity Mg ingots through the titanium wire space holder (TWSH) method a new method is

Magnesium Silicate Bioceramics for Bone Regeneration: A

With the increase in need of ideal bone graft materials magnesium silicate has been explored as resorbable bioceramics Calcium phosphate-based bioceramics are well studied and being implemented for several orthopaedic applications as they mimic the chemistry of the natural bone Although extensively used these materials do not satisfy all the essential requirements of an ideal temporary

A Novel magnesium composed PLGA/TCP porous scaffold

A NOVEL MAGNESIUM COMPOSED PLGA/TCP POROUS SCAFFOLD FABRICATED BY 3D PRINTING FOR BONE REGENERATION Yuxiao Lai a Long Li Shukui Chen a Ming Zhang Xinluan Wang Peng Zhang a Ling Qin a b aCenter for Translational Medicine Research and Development Shenzhen Institute of Advanced Technology Chinese Academy of Science China