healthy offspring from freeze-dried mouse spermatozoa

Healthy offspring from freeze

Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months Wakayama S Kamada Y Yamanaka K Kohda T Suzuki H Shimazu T Tada MN Osada I Nagamatsu A Kamimura S Nagatomo H Mizutani E Ishino F Yano S Wakayama T

Space mice and normalcy of spermatozoa DNA preserved long

Title: Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months 【Linchpin of the research】 The world's first mice (space mice) originated from space spermatozoa were born by using freeze-dried mouse spermatozoa which were returned to the ground after having been preserved on the ISS for a

Paternal diet programs offspring health through sperm

We have developed a mouse paternal low-protein diet (LPD) model to determine its impact on semen quality maternal uterine physiology and adult offspring health We observed that sperm from LPD-fed male mice displayed global hypomethylation associated with reduced testicular expression of DNA methylation and folate-cycle regulators compared

Space radiobiology needs realistic hypotheses and relevant

Aug 15 2017"If humans ever start to live permanently in space" and to verify whether assisted reproductive technology is safe in space Wakayama et al (1) maintained freeze-dried mouse spermatozoa in the International Space Station for 9 mo While these authors are aware of the risks linked to space radiation both their rationale and methodology approach raise two concerns

Mouse Sperm Kept In Space Can Still Produce Offspring

Jun 08 2017In a study published in the Proceedings of the National Academy of Sciences in 2017 researchers describe the process that led to a litter of healthy mouse pups being born from sperm preserved in space They collected samples of mouse sperm and freeze-dried it—an unusual process for sperm since most animals' sperm can't survive freeze drying and is better maintained using

Healthy offspring from freeze

Jun 06 2017When spermatozoa are freeze-dried or evaporatively dried none of the sperm survive however mouse spermatozoa can maintain the ability to generate offspring when added to water and microinjected into fresh oocytes (31 32) and this may possible with human spermatozoa in

Healthy offspring from freeze

Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months [Sayaka Wakayama Yuko Kamada Kaori Yamanaka Takashi Kohda Hiromi Suzuki Toru Shimazu Motoki N Tada Ikuko Osada Aiko Nagamatsu Satoshi Kamimura Hiroaki Nagatomo Eiji Mizutani Fumitoshi Ishino Sachiko Yano Teruhiko Wakayama]

Sperm Preservation: A Review on Current Methods and a

Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months PNAS 114(2): 5988-5993 8 Kusakabe H Szczygiel MA Whittingham DG Yanagimachi R (2001) Maintenance of genetic integrity in frozen and freeze-dried mouse spermatozoa

Sperm frozen in space produces healthy mice: study

May 23 2017In a first freeze-dried sperm stored for over nine months aboard the International Space Station (ISS) has yielded healthy mice offspring say scientists who suggest that assisted reproduction may be possible for humans living in space in the future

Maintenance of genetic integrity in frozen and freeze

Nov 20 2001Chromosome stability was maintained in mouse spermatozoa after freeze-drying or freezing without cryoprotection in a simple Tris⋅HCl buffer containing EGTA (50 mM) and NaCl (50 mM) The ability of spermatozoa to activate oocytes spontaneously was not destroyed by freeze-drying or freezing without cryoprotection in this solution Embryos derived after injecting oocytes with sperm

Assessing the tolerance to room temperature and viability

Jul 13 2018Wakayama S et al Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months Proc Natl Acad Sci USA 2017 114:5988–5993 doi: 10 1073/pnas 1701425114 [Europe PMC free article] [Google Scholar]

Assessment of three generations of mice derived by ICSI

Nevertheless once born mice derived by ICSI using freeze-dried sperm in both mouse strains were healthy and reproductively sound No major differences in litter size weaning rate and ratio were noted in the two generations of progeny (F2 and F3) of ICSI-derived offspring using freeze-dried sperm compared with that in the natural mating

Mouse sperm sent into space produces healthy IVF babies

Freeze-dried mouse sperm that spent nine months in space has successfully impregnated mice and created healthy offspring We are starting to consider space colonisation more seriously but there are still big questions about the viability of human reproduction off Earth

Healthy offspring from freeze

Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months [Sayaka Wakayama Yuko Kamada Kaori Yamanaka Takashi Kohda Hiromi Suzuki Toru Shimazu Motoki N Tada Ikuko Osada Aiko Nagamatsu Satoshi Kamimura Hiroaki Nagatomo Eiji Mizutani Fumitoshi Ishino Sachiko Yano Teruhiko Wakayama]

Why Low Sperm Counts Need Quantitative/Qualitative Analyses

Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months S Wakayama Y Kamada K Yamanaka T Kohda H Suzuki T Shimazu M N Tada I Osada A Nagamatsu S Kamimura H Nagatomo E Mizutani F Ishino S Yano T Wakayama PNAS Volume 114 Issue 23 June 2017 Pages 5988-5993

Assessing the tolerance to room temperature and viability

Finally a large number of healthy offspring were obtained from mice oocytes fertilized with FD spermatozoa stored at RT for more than one year Although the birth rate from three-month stored spermatozoa was lower than that from one-day stored spermatozoa no further reduction was observed even in one-year stored spermatozoa

Prevention of high

Dec 01 2017Chromosomes of freeze-dried mouse spermatozoa are known to be more resistant to γ-irradiation than those of spermatozoa suspended in solution Recently it was demonstrated that live offspring of mice could be produced using freeze-dried spermatozoa that had been stored on the International Space Station (outside the earth) being constantly

Space mice and normalcy of spermatozoa DNA preserved long

Title: Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months 【Linchpin of the research】 The world's first mice (space mice) originated from space spermatozoa were born by using freeze-dried mouse spermatozoa which were returned to the ground after having been preserved on the ISS for a

Development of mouse preimplantation embryos in space

In vitro development of mouse pre-implantation embryos in space (A) The embryonic culture incubator used in space experiments The incubator consists of four imaging culture chambers (indicated by the yellow dotted line and the numbers 1 2 3 and 4) two groups of culture fixation units (yellow dotted lines) a microscope (red arrow) and two module reservoirs of fixative solutions (red arrow)

Sperm frozen in space produces healthy mice: study

May 23 2017In a first freeze-dried sperm stored for over nine months aboard the International Space Station (ISS) has yielded healthy mice offspring say scientists who suggest that assisted reproduction may be possible for humans living in space in the future

Sperm in space produce healthy mouse pups on Earth

Mouse sperm stored aboard the International Space Station (ISS) for nine months has been used to produce healthy pups back on Earth Japanese researchers sent freeze-dried sperm to space to understand the long-term effects of microgravity and radiation exposure on

Have animals mated or reproduced on the International

Jan 10 2018Wakayama S Kamada Y Yamanaka K Kohda T Suzuki H Shimazu T Tada MN Osada I Nagamatsu A Kamimura S Nagatomo H Mizutani E Ishino F Yano S Wakayama T Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months

Have animals mated or reproduced on the International

Jan 10 2018Wakayama S Kamada Y Yamanaka K Kohda T Suzuki H Shimazu T Tada MN Osada I Nagamatsu A Kamimura S Nagatomo H Mizutani E Ishino F Yano S Wakayama T Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months

Assessment of three generations of mice derived by ICSI

Nevertheless once born mice derived by ICSI using freeze-dried sperm in both mouse strains were healthy and reproductively sound No major differences in litter size weaning rate and ratio were noted in the two generations of progeny (F2 and F3) of ICSI-derived offspring using freeze-dried sperm compared with that in the natural mating

Prevention of high

Dec 01 2017Chromosomes of freeze-dried mouse spermatozoa are known to be more resistant to γ-irradiation than those of spermatozoa suspended in solution Recently it was demonstrated that live offspring of mice could be produced using freeze-dried spermatozoa that had been stored on the International Space Station (outside the earth) being constantly